Buying lottery tickets is not an efficient way to increase your personal wealth. For those of you who still think you can beat the odds, there actually is a strategy. The single surefire way to win money from playing the Powerball lottery is to buy 39 tickets, each one hand-picked to contain one of the unique Powerball numbers between 1 and 39. You are then guaranteed to at least win the $3 prize. Sure, it may have cost you $39, but this is one way to “win” the lottery. Lustig says a guaranteed way to increase your chances of winning the lottery is simply by picking your own numbers versus using the "quick-pick" ticket option. ... One number doesn't win the jackpot, a set of numbers does," says Lustig. "The lazy way out is to buy quick-picks. The computer picks out the numbers.